Current Issue : January - March Volume : 2018 Issue Number : 1 Articles : 5 Articles
Introduction. A validated assessment of pruritus intensity is an important but still difficult clinical problem due to a subjective nature\nof this sensation. Objective.The aim of this studywas the creation and validation of newitch severity questionnaire assessing pruritus\nintensity. Material and Methods. A total of 148 patients with pruritic dermatoses were asked to assess pruritus intensity using 12-\nItem Pruritus Severity Score (12-PSS) and Visual Analogue Scale (VAS). Patients were also asked to complete the Dermatology Life\nQuality Index (DLQI) and Hospitality Anxiety and Depression Scale (HADS). Test-retest comparison of 12-PSS was conducted\nin 102 subjects who completed the itch questionnaire twice with the 3- to 5-day interval. Results. We have created the 12-PSS\nassessing pruritus intensity (two questions), pruritus extent (one question) and duration (one question), influence of pruritus on\nconcentration and patient psyche (four questions), and scratching as a response to pruritus stimuli (four questions). A maximum\nscoring was 22 points. The results showed strong consistency (Cronbach ...
Atopic dermatitis is an extremely common, pruritic, and frustrating disease to treat in\nboth people and animals. Atopic dermatitis is multifactorial and results from complex interactions\nbetween genetic and environmental factors. Much progress has been done in recent years in terms\nof understanding the complex pathogenesis of this clinical syndrome and the identification of new\ntreatments. As we learn more about it, we appreciate the striking similarities that exist in the clinical\nmanifestations of this disease across species. Both in animals and people, atopic disease is becoming\nincreasingly common and important similarities exist in terms of immunologic aberrations and the\npropensity for allergic sensitization. The purpose of this review is to highlight the most recent views\non atopic dermatitis in both domestic species and in people emphasizing the similarities and the\ndifferences. A comparative approach can be beneficial in understanding the natural course of this\ndisease and the variable response to existing therapies....
Reticulated pigmentation is a unique pigmentary change caused by a heterogeneous group of hereditary and acquired\ndisorders. This pigmentation is characterized by a mottled appearance, with lesions that vary in size and pigmentary content.\nThis review discusses the hereditary group of the reticulated pigmentation disorders, such as dyschromatosis symmetrica\nhereditaria, dyschromatosis universalis hereditaria, and reticulate acropigmentation of Kitamura. The clinical presentation and\nhistopathological features often overlap, making diagnosis difficult. However, each of these hereditary conditions possesses a\nunique genetic mutation, and genetic analysis is thus more useful in the diagnosis of these conditions. This article delivers\nan update regarding the clinical features, detailed histopathological description, and genetic information concerning hereditary\nreticulate pigmentary disorders and aims to provide useful background for use by clinical dermatologists and histopathologists\nwhen approaching this group of hereditary disorders....
Background: Photodynamic therapy with daylight (DL-PDT) is efficacious in treating actinic keratosis (AK), but the\nefficacy of field-directed, repetitive DL-PDT for the treatment and prophylaxis of AK in photodamaged facial skin\nhas not yet been investigated.\nMethods/design: In this multicenter, prospective, randomized, controlled, two-armed, observer-blinded trial,\npatients with a minimum of 5 mild-to-moderate AK lesions on photodamaged facial skin are randomly allocated to\ntwo treatment groups: DL-PDT with methyl aminolevulinate (MAL) and cryosurgery. In the DL-PDT group\n(experimental group), 5 treatments of the entire face are conducted over the course of 18 months. After\npreparation of the lesion and within 30 min after MAL application, patients expose themselves to daylight for 2 h.\nIn the control group, lesion-directed cryosurgery is conducted at the first visit and, in the case of uncleared or new\nAK lesions, also at visits 2 to 5. The efficacy of the treatment is evaluated at visits 2 to 6 by documenting all existing\nand new AK lesions in the face. Cosmetic results and improvement of photoaging parameters are evaluated by\nmeans of a modified Dover scale.\nPrimary outcome parameter is the cumulative number of AK lesions observed between visits 2 and 6.\nSecondary outcome parameters are complete clearance of AK, new AK lesions since the previous visit, cosmetic\nresults independently evaluated by both patient and physician, patient-reported pain (visual analogue scale), patient\nand physician satisfaction scores with cosmetic results, and patient-reported quality of life (Dermatology Life Quality\nIndex). Safety parameters are also documented (adverse events and serious adverse events).\nDiscussion: This clinical trial will assess the efficacy of repetitive DL-PDT in preventing AK and investigate possible\nrejuvenating effects of this treatment. (Trial registration: ClinicalTrials.gov Identifier: NCT02736760)....
Ischaemic insult in the skin flaps is a major problem in reconstructive surgery particularly in patients with diabetes mellitus.\nHere, we sought to investigate the effectiveness of ischaemic preconditioning (IP) on diabetic skin flaps in rat animal model.\nHundredWistar rats (90 streptozotocin treated animals and 10 nondiabetic controls) were used. Diabetes mellitus was confirmed\nby measuring glucose level in blood, HbA1c, and ketonuria.We used blood vessel clamping, hind limb tourniquet, and NO donors\n(Spermine/NO complex) to induce short-term ischaemia of tissues that will be excised for skin flaps. Animals were followed\nfor 5 days. Flaps were photographed at day 5 and percent of necrosis was determined using planimetry. Significant decrease in\npercent of necrotic tissue in all groups that received preconditioning was observed. Results show that ischaemic preconditioning\nsuppresses flap necrosis in diabetic rats irrespective of direct or remote tissue IP and irrespective of chemically or physically induced\npreischaemia. Spermine/NO complex treatment 10 minutes after the flap ischaemia suppressed tissue necrosis. Treatment with NO\nsynthase inhibitor L-NAME reversed effects of IP showing importance of NO for this process. We show that IP is a promising\napproach for suppression of tissue necrosis in diabetic flaps and potential of NO pathway as therapeutic target in diabetic flaps....
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